The role of galectin-1 in in vitro and in vivo photodynamic therapy with a galactodendritic porphyrin.

@article{Pereira2016TheRO,
  title={The role of galectin-1 in in vitro and in vivo photodynamic therapy with a galactodendritic porphyrin.},
  author={Patr{\'i}cia M Pereira and Simone Ribeiro e Silva and Jos{\'e} S Ramalho and C{\'e}lia M F Gomes and Henrique Gir{\~a}o and Jos{\'e} A S Cavaleiro and Carlos Alberto Fontes Ribeiro and Jo{\~a}o P C Tom{\'e} and Rosa Fernandes},
  journal={European journal of cancer},
  year={2016},
  volume={68},
  pages={
          60-69
        }
}
Conventional photodynamic agents used in clinic are porphyrin-based photosensitizers. However, they have low tumour selectivity, which may induce unwanted side-effects and damage to healthy tissues. In this study, we used a porphyrin with dendritic units of galactose (PorGal8) developed by us, which can target the galactose-binding protein, galectin-1, known to be overexpressed in many tumour tissues. In vitro and in vivo studies had been conducted for the validation of PorGal8 effectiveness… CONTINUE READING

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