The role of fructose in the pathogenesis of NAFLD and the metabolic syndrome

  title={The role of fructose in the pathogenesis of NAFLD and the metabolic syndrome},
  author={Jung Sub Lim and Michele Mietus-Snyder and A Valente and Jean Marc Schwarz and Robert H Lustig},
  journal={Nature Reviews Gastroenterology \&Hepatology},
Nonalcoholic fatty liver disease (NAFLD) is the most frequent liver disease worldwide, and is commonly associated with the metabolic syndrome. Secular trends in the prevalence of these diseases may be associated with the increased fructose consumption observed in the Western diet. NAFLD is characterized by two steps of liver injury: intrahepatic lipid accumulation (hepatic steatosis), and inflammatory progression to nonalcoholic steatohepatitis (NASH) (the 'two-hit' theory). In the first 'hit… 

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