The role of free radicals in asbestos-induced diseases.

  title={The role of free radicals in asbestos-induced diseases.},
  author={David W. Kamp and Philip Graceffa and William A. Pryor and Sigmund A. Weitzman},
  journal={Free radical biology & medicine},
  volume={12 4},
Asbestos exposure causes pulmonary fibrosis and malignant neoplasms by mechanisms that remain uncertain. In this review, we explore the evidence supporting the hypothesis that free radicals and other reactive oxygen species (ROS) are an important mechanism by which asbestos mediates tissue damage. There appears to be at least two principal mechanisms by which asbestos can induce ROS production; one operates in cell-free systems and the other involves mediation by phagocytic cells. Asbestos and… CONTINUE READING


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