The role of formaldehyde and S-chloromethylglutathione in the bacterial mutagenicity of methylene chloride.

@article{Graves1994TheRO,
  title={The role of formaldehyde and S-chloromethylglutathione in the bacterial mutagenicity of methylene chloride.},
  author={Rory Graves and Rohan Callander and Trevor Green},
  journal={Mutation research},
  year={1994},
  volume={320 3},
  pages={235-43}
}
Methylene chloride was less mutagenic in Salmonella typhimurium TA100/NG-11 (glutathione-deficient) compared to TA100, indicating that glutathione is involved in the activation of methylene chloride to a mutagen in bacteria. In rodents, the pathway of methylene chloride metabolism utilizing glutathione produces formaldehyde via a postulated S-chloromethylglutathione conjugate (GSCH2Cl). Formaldehyde is known to cause DNA-protein cross-links, and GSCH2Cl may act as a monofunctional DNA alkylator… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

Insights from Epidemiology into Dichloromethane and Cancer Risk

International journal of environmental research and public health • 2011
View 1 Excerpt

Workshop overview: reassessment of the cancer risk of dichloromethane in humans.

Toxicological sciences : an official journal of the Society of Toxicology • 2006
View 1 Excerpt

Similar Papers

Loading similar papers…