The role of forced swim test on neutrophil leukocytosis observed during inflammation induced by LPS in rodents

@article{Altenburg2002TheRO,
  title={The role of forced swim test on neutrophil leukocytosis observed during inflammation induced by LPS in rodents},
  author={Sonia P. Altenburg and Diana G Ventura and Vilma A. Da-Silva and Luciana Reis Malheiros and Nancy Airoldi Teixeira},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={2002},
  volume={26},
  pages={891-895}
}
Adult male rats were administered intrapleural (ipl) or intraperitoneal (i.p.) injection of lipopolysaccharide (LPS), 24 h after being submitted to forced swim test (FST). Four hours after LPS challenge, an increase in pleural and peritoneal leukocyte and neutrophil counts in animals not exposed to FST was noted. FST induced a marked increase in pleural, but not in peritoneal, neutrophil leukocytosis. The results suggest that lowered mood may increase inflammatory response to LPS.