• Chemistry, Medicine
  • Published in
    Journal of pharmaceutical…
    2009
  • DOI:10.1002/jps.21629

The role of force control agents in high-dose dry powder inhaler formulations.

@article{Begat2009TheRO,
  title={The role of force control agents in high-dose dry powder inhaler formulations.},
  author={Philippe Begat and David A. V. Morton and Jagdeep Shur and Paul Kippax and John Nicholas Staniforth and Robert Price},
  journal={Journal of pharmaceutical sciences},
  year={2009},
  volume={98 8},
  pages={
          2770-83
        }
}
The aim of this study was to determine the aerosolisation and aerodynamic properties of model inhalation particles (salbutamol sulphate and budesonide) upon coprocessing with force control agents (FCAs)-leucine, lecithin and magnesium stearate. Coprocessing of the drug particles with FCAs (5%, w/w) was conducted using mechanofusion-a novel dry mechanical fusion process. The influence of mechanofused FCAs on the entrainment and deaggregation behaviour of the drug-only formulations was… CONTINUE READING

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