The role of fluctuations and stress on the effective viscosity of cell aggregates.

@article{Marmottant2009TheRO,
  title={The role of fluctuations and stress on the effective viscosity of cell aggregates.},
  author={Philippe Marmottant and Abbas Mgharbel and Jos K{\"a}fer and Benjamin Audren and Jean-Paul Rieu and Jean-Claude Vial and Boudewijn van der Sanden and Athanasius F. M. Mar{\'e}e and François Graner and H{\'e}l{\'e}ne Delano{\"e}-Ayari},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 41},
  pages={17271-5}
}
Cell aggregates are a tool for in vitro studies of morphogenesis, cancer invasion, and tissue engineering. They respond to mechanical forces as a complex rather than simple liquid. To change an aggregate's shape, cells have to overcome energy barriers. If cell shape fluctuations are active enough, the aggregate spontaneously relaxes stresses ("fluctuation-induced flow"). If not, changing the aggregate's shape requires a sufficiently large applied stress ("stress-induced flow"). To capture this… CONTINUE READING
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The cellular Potts model and biophysical properties of cells, tissues and morphogenesis. Single Cell Based Models in Biology and Medicine, eds Anderson ARA, Chaplain MAJ

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