The role of flavonoid antioxidant, morin in improving procarbazine-induced oxidative stress on testicular function in rat

@article{Olayinka2019TheRO,
  title={The role of flavonoid antioxidant, morin in improving procarbazine-induced oxidative stress on testicular function in rat},
  author={Ebenezer Tunde Olayinka and Ayokanmi Ore and Oluwatobi Adewumi Adeyemo and Olaniyi Solomon Ola},
  journal={Porto Biomedical Journal},
  year={2019},
  volume={4}
}
Background: Procarbazine (PCZ) is an effective chemotherapeutic drug used in the treatment of lymphoma; however, oxidative stress–mediated testicular toxicity is a major side effect. Recently, therapeutic intervention using flavonoids against oxidative stress–related pathologies is gaining more attention. Morin (MOR) is a natural flavonoid with proven antioxidant activity. This study was designed therefore to evaluate the potential role of MOR in ameliorating PCZ-induced testicular oxidative… Expand
Ameliorative effect of morin on dutasteride-tamsulosin-induced testicular oxidative stress in rat
TLDR
Results indicated the protective ability of morin against Dutasteride-Tamsulosin-induced testicular toxicity and oxidative stress in Wistar rat. Expand
Morin attenuates acrylamide-induced testicular toxicity in rats by regulating the NF-κB, Bax/Bcl-2 and PI3K/Akt/mTOR signaling pathways.
TLDR
Treatment with morin could significantly decrease MDA level and considerably increase the activity of antioxidant enzymes and GSH level in the testicular tissue of the AC-treated rats, showing the possible protective mechanism of morin, a potential therapeutic agent for AC-induced testicular toxicity. Expand
MORIN ATTENUATES DUTASTERIDE/TAMSULOSIN-INDUCED HEPATIC OXIDATIVE STRESS IN RAT
Dutasteride-Tamsulosin (DUT-TAM) is a combination drug for the treatment of symptoms of prostate enlargement (benign prostatic hyperplasia, BPH). Despite the efficacy, it is associated with some sideExpand
Antioxidants Isolated from Elaeagnus umbellata (Thunb.) Protect against Bacterial Infections and Diabetes in Streptozotocin-Induced Diabetic Rat Model
TLDR
Morin exhibited high antioxidant, antibacterial, and antidiabetic potentials as compared to phloroglucinol and 1-hexyl benzene, that could, therefore, be considered as a promising therapeutic agent to treat diabetes mellitus and bacterial infections. Expand
The Impact of Oxidative Stress on Testicular Function and the Role of Antioxidants in Improving it: A Review.
TLDR
Use of antioxidants and development of antioxidant therapy can break down the oxidative chain reaction and play a very significant role in increasing the body's capacity to fight free radical-induced oxidative stress, and therefore improve the process of spermatogenesis. Expand
Morin as an imminent functional food ingredient: an update on its enhanced efficacy in the treatment and prevention of metabolic syndromes.
TLDR
Based on the prevailing information rationalizing its medicinal use, morin can be identified as a therapeutic agent for the expansion of human health. Expand
Morin-5′-Sulfonic Acid Sodium Salt (NaMSA) Attenuates Cyclophosphamide-Induced Histological Changes in Genitourinary Tract in Rats—Short Report
TLDR
It is suggested that NaMSA may attenuate CPX-induced histological changes in rat urogenital tract and may also attenuate the effect of morin-5′-sulfonic acid sodium salt on CPX's toxicity in rats. Expand
EFFECT OF HESPERETIN TREATMENT ON BLOOD GLUCOSE LEVEL, SPERMATOZOA QUALITY, AND SPERMATOZOA QUANTITY IN ALLOXAN-INDUCED DIABETIC MICE
TLDR
Overall, hesperetin decreased blood glucose levels, increased spermatozoa quantity, and improved the spermutozoa quality in alloxan-induced diabetes mellitus mice. Expand
PRESERVATION OF ANTIOXIDANT DEFENSE SYSTEM BY MORIN IN BICALUTAMIDE-INDUCED RAT TESTICULAR TOXICITY
* Olayinka, E.T. , Ore, A., Olotu, O.O., Ogbuji, V.U., Adeyemo, O.A., Ola, O.S. Biochemistry Division, Department of Chemical Sciences, Faculty of Natural Sciences, Ajayi Crowther University, Oyo,Expand
Morin attenuates pyroptosis of nucleus pulposus cells and ameliorates intervertebral disc degeneration via inhibition of the TXNIP/NLRP3/Caspase-1/IL-1β signaling pathway.
TLDR
Results indicate that TXNIP promote pyroptosis via NLRP3/Caspase-1/IL-1β signaling pathway in NP cell and morin may be a useful therapeutic agent for IDD. Expand

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