The role of fibrillin and microfibril binding proteins in elastin and elastic fibre assembly

@article{Godwin2019TheRO,
  title={The role of fibrillin and microfibril binding proteins in elastin and elastic fibre assembly},
  author={Alan R.F. Godwin and Mukti Singh and Michael P. Lockhart-Cairns and Yasmene F. Alanazi and Stuart A. Cain and Clair Baldock},
  journal={Matrix Biology},
  year={2019},
  volume={84},
  pages={17 - 30}
}
Structural studies of elastic fibre and microfibrillar proteins
The fibrillin microfibril/elastic fibre network: A critical extracellular supramolecular scaffold to balance skin homoeostasis
TLDR
The current understanding of the underlying pathomechanisms leading to fibrillin‐dependent fibrosis as well as forms of cutis laxa caused by mutational inactivation of FMF‐associated ligands are given.
Structure of Elastin.
TLDR
The structure stability, elastic resilience, bioactivity, and ability of self-assembly make elastin a highly desirable candidate for the fabrication of biomaterials, and this chapter centers on introducing the structure of those two materials.
The Multiple Functions of Fibrillin-1 Microfibrils in Organismal Physiology
TLDR
A brief review summarizes relevant findings supporting the conclusion that fibrillin-1 mutations cause pleiotropic manifestations in Marfan syndrome in mice that are distinct and organ-specific.
Elastic Fibre Proteins in Elastogenesis and Wound Healing
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Key players in elastogenesis are described: fibrillin-1, tropoelastin, latent TGFβ binding protein-4, and fibulin-4 and -5, and their interactions involved in forming the elastic fibre network are described.
Perlecan in Pericellular Mechanosensory Cell-Matrix Communication, Extracellular Matrix Stabilisation and Mechanoregulation of Load-Bearing Connective Tissues
TLDR
Perlecan acts as a transport proteoglycan carrying poorly soluble, lipid-modified proteins such as the Wnt or Hedgehog families facilitating the establishment of morphogen gradients that drive tissue morphogenesis.
Recombination and Purification of Elastin-Like Polypeptides.
TLDR
This chapter introduces the detailed protocol for the preparation of ELPs using genetic recombination, including DNA recombinations, expression, and purification, to provide methodological guidance for preparation and application of ELP materials.
The “Elastic Perspective” of SARS-CoV-2 Infection and the Role of Intrinsic and Extrinsic Factors
TLDR
Within the lungs, destruction of the elastic network may lead to the permanent impairment of pulmonary function, thus suggesting that elastases can be a promising target to preserve the elastic component in COVID-19 patients.
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