The role of fat depletion in the biological benefits of caloric restriction.

  title={The role of fat depletion in the biological benefits of caloric restriction.},
  author={Nir Barzilai and Ilan Gabriely},
  journal={The Journal of nutrition},
  volume={131 3},
One of the most robust observations in the biology of aging is that caloric restriction (CR) extends life in a variety of species. Although CR results in substantial decrease in fat mass, the role of fat in life extension was considered minimal. Indeed, in the fields of obesity and diabetes, the amount of fat has been directly implicated in the metabolic consequences. Since it became apparent that fat is a massive endocrine tissue, some of its roles have been recently revised. Many of the… CONTINUE READING
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