The role of fascin in the migration and invasiveness of malignant glioma cells.

  title={The role of fascin in the migration and invasiveness of malignant glioma cells.},
  author={Jeong Hyun Hwang and Christian A. Smith and Bodour Salhia and James T. Rutka},
  volume={10 2},
Malignant glioma is the most common primary brain tumor, and its ability to invade the surrounding brain parenchyma is a leading cause of tumor recurrence and treatment failure. Whereas the molecular mechanisms of glioma invasion are incompletely understood, there is growing evidence that cytoskeletal-matrix interactions contribute to this process. Fascin, an actin-bundling protein, induces parallel actin bundles in cell protrusions and increases cell motility in multiple human malignancies… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 37 extracted citations


Publications referenced by this paper.
Showing 1-10 of 56 references

Role of fascin in filopodial protrusion

The Journal of cell biology • 2006
View 6 Excerpts
Highly Influenced

Role of fascin in the proliferation and invasiveness of esophageal carcinoma cells.

Biochemical and biophysical research communications • 2005
View 5 Excerpts
Highly Influenced

Fascins, and their roles in cell structure and function.

BioEssays : news and reviews in molecular, cellular and developmental biology • 2002
View 4 Excerpts
Highly Influenced

Chemoradiotherapy in malignant glioma: standard of care and future directions.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology • 2007
View 1 Excerpt

Similar Papers

Loading similar papers…