The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men.

@article{Chan2003TheRO,
  title={The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men.},
  author={Jean L. Chan and Kathleen A. Heist and Alex M Depaoli and Johannes D. Veldhuis and Christos Socrates Mantzoros},
  journal={The Journal of clinical investigation},
  year={2003},
  volume={111 9},
  pages={1409-21}
}
To elucidate the role of leptin in regulating neuroendocrine and metabolic function during an acute fast, six to eight healthy, lean men were studied under four separate conditions: a baseline fed state and three 72-hour fasting studies with administration of either placebo, low-dose recombinant-methionyl human leptin (r-metHuLeptin), or replacement-dose r-metHuLeptin designed to maintain serum leptin at levels similar to those in the fed state. Replacement-dose r-metHuLeptin administered… CONTINUE READING
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References

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Showing 1-10 of 56 references

A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

  • K Clement
  • Nature .
  • 1998
Highly Influential
10 Excerpts

Starvation. In Principles and practice of endocrinology and metabolism

  • R. S. MacDonald, R. J. Smith
  • 2001
Highly Influential
5 Excerpts

Beneficial effects of leptin on obesity, T cell hyporesponsiveness and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency

  • Farooqi, I.S
  • J. Clin. Invest
  • 2002
3 Excerpts

Neuropeptide Y 1 and Y 5 receptors mediate the effects of neuropeptide Y on the hypothalamicpituitarythyroid axis

  • C. Fekete
  • Endocrinology
  • 2002

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