The role of factor XI in thrombin generation induced by low concentrations of tissue factor.

Abstract

Thrombin generation has been studied in the plasma of severely factor XI deficient patients under conditions in which contact activation did not play a role. In platelet-rich as well as platelet-poor plasma, thrombin generation was dependent upon the presence of factor XI at tissue factor concentrations of between 1 and 20 pg/ml i.e. approximately 0.01 to 0… (More)

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@article{Keularts2001TheRO, title={The role of factor XI in thrombin generation induced by low concentrations of tissue factor.}, author={Irene M. L. W. Keularts and Ariella Zivelin and Uri Seligsohn and Hendrik Coenraad Hemker and Suzette B{\'e}guin}, journal={Thrombosis and haemostasis}, year={2001}, volume={85 6}, pages={1060-5} }