The role of extracellular matrix in small-cell lung cancer.

  title={The role of extracellular matrix in small-cell lung cancer.},
  author={Robert C Rintoul and Tariq Sethi},
  journal={The Lancet. Oncology},
  volume={2 7},
Lung cancer is the most common fatal malignant disease in the western world, accounting for 42,000 deaths each year in the UK alone. Small-cell lung cancer (SCLC), accounts for 25% of all lung cancers. It is a particularly aggressive form of the disease, characterised by widespread metastases and the development of resistance to chemotherapy. Even with combination chemotherapy and radiotherapy treatments, the 5-year survival is only about 5%. We review recent insights into the mechanisms… CONTINUE READING
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