The role of extracellular matrix in human astrocytoma migration and proliferation studied in a microliter scale assay

@article{Berens1994TheRO,
  title={The role of extracellular matrix in human astrocytoma migration and proliferation studied in a microliter scale assay},
  author={Michael E. Berens and Monique D. Rief and Melinda A. Loo and Alf Giese},
  journal={Clinical & Experimental Metastasis},
  year={1994},
  volume={12},
  pages={405-415}
}
Ligands in the extracellular matrix (ECM) are known to mediate migration of normal as well as tumor cells via adhesion molecules such as the integrin receptor family. We developed a microliter scale (15-20 fu total volume) monolayer migration assay to investigate the ability of astrocytoma cells to disperse on surfaces coated with purified human ECM protein ligands. In this system the rate of radial migration of the cell population was constant over time. For human astrocytoma cell lines U-251… CONTINUE READING
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Growth properties and oncogene expression in 2 newly derived glioma cell lines: assessment of growth determinants

  • ME Berens, AS Weisman, DR Spencer
  • Proc AACR,
  • 1991

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