The role of extracellular Ca2+ and Na+ in paf-acether-induced human platelet activation.

Abstract

The dependence of paf-acether (paf)-induced human platelet activation on extracellular Ca2+ and Na+ was examined by quantitating aggregation, secretion and thromboxane (Tx) formation in the presence of physiological and/or low concentrations of Ca2+ and/or Na+. In the presence of 2 mM Ca2+ and 140 mM Na+, paf induced a dose-dependent reversible aggregation… (More)

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