The role of estrogen in the maintenance of primate pregnancy.

  title={The role of estrogen in the maintenance of primate pregnancy.},
  author={Eugene D. Albrecht and Graham W Aberdeen and Gerald J. Pepe},
  journal={American journal of obstetrics and gynecology},
  volume={182 2},
OBJECTIVE The aim of this study was to determine the role of estrogen in pregnancy maintenance in baboons by suppressing estrogen synthesis through administration of a highly specific nonsteroidal aromatase inhibitor, CGS 20267. STUDY DESIGN CGS 20267 was administered subcutaneously at maximal dosages of 2.0 mg/d to pregnant baboons (n = 24) daily beginning on either day 30 (n = 8), day 60 (n = 8), or day 100 (n = 8) of gestation (normal length of gestation is 184 days) until animals… CONTINUE READING
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