The role of erbB2 signal transduction pathways in human breast cancer

  title={The role of erbB2 signal transduction pathways in human breast cancer},
  author={R. Lupu and M. Lippman},
  journal={Breast Cancer Research and Treatment},
SummaryThe erbB2 receptor is expressed at very high levels in nearly 30% of human breast cancer patients and plays an important role in the transformation and the prognosis of breast cancer. While evidence accumulates to support the relationship between erbB2 overexpression and poor overall survival in human breast cancer, understanding of the biological consequence(s) of erbB2 overexpression remains elusive. Our recent discovery, cloning, sequencing, and expression of the erbB2 ligand (gp30… Expand
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