The role of epithelial P2Y2 and P2Y4 receptors in the regulation of intestinal chloride secretion.

@article{Ghanem2005TheRO,
  title={The role of epithelial P2Y2 and P2Y4 receptors in the regulation of intestinal chloride secretion.},
  author={Esam Ghanem and Bernard Robaye and Teresinha Leal and Jens Leipziger and Willy van Driessche and R. Beauwens and J. M. Boeynaems},
  journal={British journal of pharmacology},
  year={2005},
  volume={146 3},
  pages={
          364-9
        }
}
UTP-induced chloride secretion by the intestinal mucosa mounted in Ussing chambers was assessed by measurement of the short-circuit current (I(sc)) in the presence of phloridzin in the case of jejunum or amiloride in the case of colon to eliminate any contribution of electrogenic Na(+) movement to the net ionic transport. Since we have previously demonstrated the absence of chloride-secretory response to apical UTP in the jejunum from P2Y(4)-null mice, in the present study we studied the… CONTINUE READING

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