The role of epigenetics in aging and autoimmunity.

@article{GrolleauJulius2010TheRO,
  title={The role of epigenetics in aging and autoimmunity.},
  author={Annabelle Grolleau-Julius and Donna D Ray and Raymond L. Yung},
  journal={Clinical reviews in allergy & immunology},
  year={2010},
  volume={39 1},
  pages={
          42-50
        }
}
The decline in immunocompetence with age is accompanied by the increase in the incidence of autoimmune diseases. Aging of the immune system, or immunosenescence, is characterized by a decline of both T and B cell function, and paradoxically the presence of low-grade chronic inflammation. There is growing evidence that epigenetics, the study of inherited changes in gene expression that are not encoded by the DNA sequence itself, changes with aging. Interestingly, emerging evidence suggests a key… CONTINUE READING
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