The role of epigenetics and miRNAs in neuroblastoma development

Abstract

Introduction Neuroblastoma (NB) is an often fatal pediatric cancer that arises from the precursor cells of the sympathetic nervous system. 13-Cis retinoic acid is used to treat high-risk disease. A derivative, all-trans-retinoic acid (ATRA) causes genome-wide demethylation in NB cells by up-regulating miRNAs such as miR-152 and miR-26a/b which are predicted… (More)

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@inproceedings{Rupani2012TheRO, title={The role of epigenetics and miRNAs in neuroblastoma development}, author={KV Rupani and Shibandri Das and R Stallings}, year={2012} }