The role of epigenetic variation in the pathogenesis of systemic lupus erythematosus

@inproceedings{Hughes2011TheRO,
  title={The role of epigenetic variation in the pathogenesis of systemic lupus erythematosus},
  author={Travis Hughes and Amr H. Sawalha},
  booktitle={Arthritis research & therapy},
  year={2011}
}
The focus of the present review is on the extent to which epigenetic alterations influence the development of systemic lupus erythematosus. Lupus is a systemic autoimmune disease characterized by the production of autoantibodies directed at nuclear self-antigens. A DNA methylation defect in CD4+ T cells has long been observed in idiopathic and drug-induced lupus. Recent studies utilizing high-throughput technologies have further characterized the nature of the DNA methylation defect in lupus… CONTINUE READING
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