The role of epigenetic mechanisms and processes in autoimmune disorders

@inproceedings{Greer2012TheRO,
  title={The role of epigenetic mechanisms and processes in autoimmune disorders},
  author={Judith M. Greer and Pamela A. McCombe},
  booktitle={Biologics : targets & therapy},
  year={2012}
}
The lack of complete concordance of autoimmune disease in identical twins suggests that nongenetic factors play a major role in determining disease susceptibility. In this review, we consider how epigenetic mechanisms could affect the immune system and effector mechanisms in autoimmunity and/or the target organ of autoimmunity and thus affect the development of autoimmune diseases. We also consider the types of stimuli that lead to epigenetic modifications and how these relate to the… CONTINUE READING
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