The role of epidermal growth factor receptor in ethanol-mediated inhibition of activator protein-1 transactivation.

Abstract

A potential mechanism underlying ethanol-induced alterations in gene expression is the disruption of transcription factor activity. Growth factor receptors, particularly receptor tyrosine kinases, play an important role in modulating many biological effects of ethanol. We demonstrated here that the expression of epidermal growth factor receptor (EGFR… (More)

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