The role of epidermal growth factor and its receptors in mammalian CNS.

@article{Wong2004TheRO,
  title={The role of epidermal growth factor and its receptors in mammalian CNS.},
  author={Richard Wing Chuen Wong and Laurent Guillaud},
  journal={Cytokine & growth factor reviews},
  year={2004},
  volume={15 2-3},
  pages={147-56}
}
Epidermal growth factor (EGF) is a common mitogenic factor that stimulates the proliferation of different types of cells, especially fibroblasts and epithelial cells. EGF activates the EGF receptor (EGFR/ErbB), which initiates, in turn, intracellular signaling. EGFR family is also expressed in neurons of the hippocampus, cerebellum, and cerebral cortex in addition to other regions of the central nervous system (CNS). EGF enhances the differentiation, maturation and survival of a variety of… CONTINUE READING