The role of environmental exposure to peanut in the development of clinical allergy to peanut

@article{Foong2017TheRO,
  title={The role of environmental exposure to peanut in the development of clinical allergy to peanut},
  author={R X Foong and Helen Annaruth Brough},
  journal={Clinical \& Experimental Allergy},
  year={2017},
  volume={47},
  pages={1232 - 1238}
}
The prevalence of peanut allergy has increased over the years and still remains one of the most common causes of food‐related anaphylaxis. The way in which peanut sensitization occurs has been explored, such as via maternal consumption in pregnancy, via breastmilk and through a disrupted skin barrier. It has previously been shown that environmental exposure to aeroallergens in household dust can be a risk factor for the development of allergic asthma. There is an increasing body of evidence… 
View on Wiley
ncbi.nlm.nih.gov
17 Citations
Background Citations
5

17 Citations

A complicated relationship between peanut environmental exposure and the development of allergic sensitization to peanuts
  • G. Roberts
  • Medicine
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 2018
TLDR
Predicting whether post-natal environmental peanut exposure is associated with later allergic sensitization to peanut in a population-based cohort is difficult, but it is predicted that a relationship is seen but only in those with a family history of atopy.
Potential Factors Related to Food Allergy Development
TLDR
Environmental factors that have been linked to increased risk of food allergy, including damaged skin barriers, changes in infant feeding habits, reduced microbial exposure, and reduced sun exposure are summarized.
Peanut Allergy: Characteristics and Approaches for Mitigation.
TLDR
This study represents the current knowledge about the alterations in allergenic properties of peanut via different processing mechanisms as well as evaluating its future potential, geographical based data on increasing sensitization, clinical relevance, eliciting dose, and current management of peanut allergy.
Peanut allergy among Mexican adults with allergic respiratory diseases: prevalence and clinical manifestations.
TLDR
Prevalence of peanut allergy among adults that have been diagnosed with either asthma or allergic rhinitis is established and cutaneous symptoms, primarily affecting the pharynx and the palate, are described.
Factors Associated with Frequency of Peanut Consumption in Korea: A National Population-Based Study
TLDR
The peanut consumption of Koreans is investigated using national representative data from the Korean National Health and Nutrition Examination Survey 2012–2016 to examine the association between sociodemographic and dietary factors and the frequency of peanut intake.
Comparing the Effectiveness of Oral Immunotherapy and Epicutaneous Immunotherapy on the Desensitization of Peanut Allergies
TLDR
A review compiled subjects from various studies to see which methodology is most effective in the prevention of peanut allergies and it is evident that OIT is the more effective treatment.
Asthma and Food Allergies
TLDR
A narrative review looks at the relationship between food allergy and asthma and how they are linked to one another and suggests early intervention strategies in clinical practice.
Food Allergy and Intolerance: A Narrative Review on Nutritional Concerns
TLDR
It is concluded that a correct diagnostic approach and dietary control of both immune- and non-immune-mediated food-induced diseases might minimize the nutritional gaps in patients, thus helping to improve their quality of life and reduce the economic costs of their management.
Extract and component‐specific sensitization patterns in Canadian moderate‐to‐severe preschool asthmatics
TLDR
B baseline allergic sensitization patterns observed within a well-characterized high-risk Canadian preschool cohort with moderate-to-severe asthma are reported.
Abundance and Stability as Common Properties of Allergens
TLDR
This review will focus on recent studies which examine two such factors: abundance and stability, which highlight the multifaceted nature of immunological sensitization, and further inform the understanding of some of these other factors and their contribution to allergic disease.
...
...

References

SHOWING 1-10 OF 76 REFERENCES
Atopic dermatitis increases the effect of exposure to peanut antigen in dust on peanut sensitization and likely peanut allergy
Natural history of peanut allergy
TLDR
This review will focus on the mechanism of allergic sensitization to peanuts and the natural history of peanut allergy as it is currently evolving.
Peanut allergy: Effect of environmental peanut exposure in children with filaggrin loss-of-function mutations
Household peanut consumption as a risk factor for the development of peanut allergy.
A novel model of sensitization and oral tolerance to peanut protein
TLDR
Results show that oral tolerance to peanut can be induced experimentally but that peanut proteins have a potent sensitizing effect, and can be used to define regulatory mechanisms following oral exposure to allergenic proteins on local, mucosal and systemic immunity.
Management of peanut allergy
TLDR
Recent developments in the management of peanut allergy, such as immunotherapy, have shown some promise as an active form of treatment, but larger studies are required to further investigate safety and efficacy.
Maternal consumption of peanut during pregnancy is associated with peanut sensitization in atopic infants.
Peanut allergen in house dust of eating area and bed – a risk factor for peanut sensitization?
TLDR
Investigation of whether peanut proteins are detectable in house dust of different household areas found peanut was detectable in 19 of 21 households in the eating area and/or in bed, and the frequency of peanut consumption correlated with peanut levels.
Peanut protein in household dust is related to household peanut consumption and is biologically active.
Randomized trial of peanut consumption in infants at risk for peanut allergy.
TLDR
The early introduction of peanuts significantly decreased the frequency of the development of peanut allergy among children at high risk for this allergy and modulated immune responses to peanuts.
...
...