The role of environmental exposure to peanut in the development of clinical allergy to peanut

  title={The role of environmental exposure to peanut in the development of clinical allergy to peanut},
  author={R X Foong and Helen Annaruth Brough},
  journal={Clinical \& Experimental Allergy},
  pages={1232 - 1238}
The prevalence of peanut allergy has increased over the years and still remains one of the most common causes of food‐related anaphylaxis. The way in which peanut sensitization occurs has been explored, such as via maternal consumption in pregnancy, via breastmilk and through a disrupted skin barrier. It has previously been shown that environmental exposure to aeroallergens in household dust can be a risk factor for the development of allergic asthma. There is an increasing body of evidence… 
A complicated relationship between peanut environmental exposure and the development of allergic sensitization to peanuts
  • G. Roberts
  • Medicine
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 2018
Predicting whether post-natal environmental peanut exposure is associated with later allergic sensitization to peanut in a population-based cohort is difficult, but it is predicted that a relationship is seen but only in those with a family history of atopy.
Potential Factors Related to Food Allergy Development
Environmental factors that have been linked to increased risk of food allergy, including damaged skin barriers, changes in infant feeding habits, reduced microbial exposure, and reduced sun exposure are summarized.
Peanut Allergy: Characteristics and Approaches for Mitigation.
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A review compiled subjects from various studies to see which methodology is most effective in the prevention of peanut allergies and it is evident that OIT is the more effective treatment.
Asthma and Food Allergies
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B baseline allergic sensitization patterns observed within a well-characterized high-risk Canadian preschool cohort with moderate-to-severe asthma are reported.
Abundance and Stability as Common Properties of Allergens
This review will focus on recent studies which examine two such factors: abundance and stability, which highlight the multifaceted nature of immunological sensitization, and further inform the understanding of some of these other factors and their contribution to allergic disease.


Natural history of peanut allergy
This review will focus on the mechanism of allergic sensitization to peanuts and the natural history of peanut allergy as it is currently evolving.
Household peanut consumption as a risk factor for the development of peanut allergy.
A novel model of sensitization and oral tolerance to peanut protein
Results show that oral tolerance to peanut can be induced experimentally but that peanut proteins have a potent sensitizing effect, and can be used to define regulatory mechanisms following oral exposure to allergenic proteins on local, mucosal and systemic immunity.
Management of peanut allergy
Recent developments in the management of peanut allergy, such as immunotherapy, have shown some promise as an active form of treatment, but larger studies are required to further investigate safety and efficacy.
Maternal consumption of peanut during pregnancy is associated with peanut sensitization in atopic infants.
Peanut allergen in house dust of eating area and bed – a risk factor for peanut sensitization?
Investigation of whether peanut proteins are detectable in house dust of different household areas found peanut was detectable in 19 of 21 households in the eating area and/or in bed, and the frequency of peanut consumption correlated with peanut levels.
Peanut protein in household dust is related to household peanut consumption and is biologically active.
Randomized trial of peanut consumption in infants at risk for peanut allergy.
The early introduction of peanuts significantly decreased the frequency of the development of peanut allergy among children at high risk for this allergy and modulated immune responses to peanuts.