The role of environmental antigens in the spontaneous development of autoimmunity in MRL-lpr mice.

@article{Maldonado1999TheRO,
  title={The role of environmental antigens in the spontaneous development of autoimmunity in MRL-lpr mice.},
  author={Michelle Maldonado and Vellalore N. Kakkanaiah and Glen C Macdonald and F Chen and Elizabeth A. Reap and Edward J Balish and Wolfgang Farkas and J. Charles Jennette and Michael Madaio and Brian L. Kotzin and Philip L. Cohen and Robert A. Eisenberg},
  journal={Journal of immunology},
  year={1999},
  volume={162 11},
  pages={6322-30}
}
It has been proposed that the "normal" stimulation of the immune system that occurs from interactions with environmental stimuli, whether infectious or dietary, is necessary for the initiation and/or continuation of autoimmunity. We tested this hypothesis by deriving a group of MRL-lpr mice into a germfree (GF) environment. At 5 mo of age, no differences between GF and conventional MRL-lpr mice were noted in lymphoproliferation, flow cytometric analysis of lymph node cells (LN), or histologic… CONTINUE READING