The role of endothelin in the pathogenesis of vasospasm following subarachnoid haemorrhage.

@article{Ide1989TheRO,
  title={The role of endothelin in the pathogenesis of vasospasm following subarachnoid haemorrhage.},
  author={Kaori Ide and Kenta Yamakawa and Tadayoshi Nakagomi and Tomio Sasaki and Isamu Saito and Hiroko Kurihara and M Yosizumi and Yoshikazu Yazaki and Kintomo Takakura},
  journal={Neurological research},
  year={1989},
  volume={11 2},
  pages={
          101-4
        }
}
The purpose of the present study was to evaluate the vasocontractile activity of endothelin, a newly isolated endothelium-derived constrictor peptide, in canine basilar arteries in vitro and in vivo. Endothelin at concentrations of 10(-12) M approximately 3 X 10(-8) M elicited dose-dependent contractions of canine basilar arteries in vitro. The maximum tension was larger than that induced by 40 mM KCl. The EC50 value was 1.9 +/- 0.6 X 10(-9) M (mean +/- SEM). The endothelin-induced contraction… CONTINUE READING

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