The role of endothelin-1 in regulating human granulosa cell proliferation and steroidogenesis in vitro.

@article{Kamada1995TheRO,
  title={The role of endothelin-1 in regulating human granulosa cell proliferation and steroidogenesis in vitro.},
  author={Suguru Kamada and Peter F. Blackmore and Tomoka Kubota and Sergio Carlos Oehninger and Yasuo Asada and Kereen B Gordon and Gary D. Hodgen and Takeshi Aso},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1995},
  volume={80 12},
  pages={3708-14}
}
The effects of endothelin-1 (ET-1) on luteinized human granulosa cells (L-HGCs) have not been examined. It is well known that there are differences of actions of several autocrine/paracrine regulators between L-HGCs and GCs of other species, and therefore the present study was designed to examine the effects of ET-1 1) on intracellular Ca2+ concentrations ([Ca2+]i) using the Ca(2+)-responsive fluorescent indicator Fura-2, 2) on cell proliferation by the nonradioactive method using… CONTINUE READING