The role of endothelial cells on the alterations in vascular reactivity induced by insulin-dependent diabetes mellitus: effects of insulin treatment.

@article{Karasu1993TheRO,
  title={The role of endothelial cells on the alterations in vascular reactivity induced by insulin-dependent diabetes mellitus: effects of insulin treatment.},
  author={Çimen Karasu and Vecdi Melih Altan},
  journal={General pharmacology},
  year={1993},
  volume={24 3},
  pages={743-55}
}
1. In this study, the maximal contractile responses to noradrenaline (NA) were significantly increased but pD2 values (sensitivity) were not significantly altered in aortas with endothelium from insulin-dependent (ID)-diabetic rats when compared to their controls. 2. Removal of the endothelium resulted in a significant increase in the maximum response of… CONTINUE READING