The role of endogenous serotonin in methamphetamine-induced neurotoxicity to dopamine nerve endings of the striatum.

@article{Thomas2010TheRO,
  title={The role of endogenous serotonin in methamphetamine-induced neurotoxicity to dopamine nerve endings of the striatum.},
  author={David M Thomas and Mariana Angoa P{\'e}rez and Dina M Francescutti-Verbeem and Mrudang M. Shah and Donald M Kuhn},
  journal={Journal of neurochemistry},
  year={2010},
  volume={115 3},
  pages={595-605}
}
Methamphetamine (METH) is a neurotoxic drug of abuse that damages the dopamine (DA) neuronal system in a highly delimited manner. The brain structure most affected by METH is the striatum where long-term DA depletion and microglial activation are maximal. Endogenous DA has been implicated as a critical participant in METH-induced neurotoxicity, most likely as a substrate for non-enzymatic oxidation by METH-generated reactive oxygen species. The striatum is also extensively innervated by… CONTINUE READING