The role of endogenous opioids as mediators of the hypothermic effects of intrathecally administered calcium and calcitonin gene-related peptide in mice.

Abstract

To the authors' knowledge, the effect of i.t. administered calcium on thermoregulation in mice has not been investigated. Calcium administration (i.t.) induced hypothermia in mice. It was found that calcitonin gene-related peptide (CGRP) (i.t.) also produced hypothermia. Because opioids have well documented thermoregulatory effects, the authors evaluated… (More)

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@article{Smith1993TheRO, title={The role of endogenous opioids as mediators of the hypothermic effects of intrathecally administered calcium and calcitonin gene-related peptide in mice.}, author={F. L. Smith and Stacy Welch and Daniel S. Dombrowski and William L. Dewey}, journal={The Journal of pharmacology and experimental therapeutics}, year={1993}, volume={266 3}, pages={1407-15} }