The role of endogenous heme synthesis and degradation domain cysteines in cellular iron-dependent degradation of IRP2.

@article{Bourdon2003TheRO,
  title={The role of endogenous heme synthesis and degradation domain cysteines in cellular iron-dependent degradation of IRP2.},
  author={Emmanuel Bourdon and Dae-Kyung Kang and Manik Chandra Ghosh and Steven K. Drake and Jane S Wey and Rodney L Levine and Tracey A Rouault},
  journal={Blood cells, molecules & diseases},
  year={2003},
  volume={31 2},
  pages={247-55}
}
Iron regulatory protein 2 (IRP2) is a mammalian cytosolic iron-sensing protein that regulates expression of iron metabolism proteins, including ferritin and transferrin receptor 1. IRP2 is ubiquitinated and degraded by the proteasome in iron-replete cells but is relatively stable in iron-depleted cells. Recent work has shown that IRP2 contains a unique 73-amino-acid domain that binds iron in vitro and undergoes iron-dependent oxidation and cleavage (J. Biol. Chem. 278 (2003), 14857). Several… CONTINUE READING

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