The role of endocytosis in regulating the strength of hippocampal synapses.

  title={The role of endocytosis in regulating the strength of hippocampal synapses.},
  author={Bj{\"o}rn Granseth and Leon Lagnado},
  journal={The Journal of physiology},
  volume={586 24},
The readily releasable pool of vesicles (RRP) varies in size during synaptic activity and is replenished by recruitment from the reserve pool as well as vesicle retrieval after fusion. To investigate which of these steps is rate limiting in supplying vesicles to the RRP, we measured the effects of changes in temperature in cultured hippocampal neurons, where higher average rates of release can be maintained as the temperature is increased. Using a pHluorin-based reporter of exocytosis and… CONTINUE READING
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