The role of endocannabinoids in pain modulation

  title={The role of endocannabinoids in pain modulation},
  author={Panagiotis Zogopoulos and Ioanna Vasileiou and Efstratios S. Patsouris and Stamatios Theocharis},
  journal={Fundamental \& Clinical Pharmacology},
The endocannabinoid system (ES) is comprised of cannabinoid (CB) receptors, their endogenous ligands (endocannabinoids), and proteins responsible for their metabolism. Endocannabinoids serve as retrograde signaling messengers in GABAergic and glutamatergic synapses, as well as modulators of postsynaptic transmission, that interact with other neurotransmitters. Physiological stimuli and pathological conditions lead to differential increases in brain endocannabinoids that regulate distinct… 
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