The role of elastin and collagen in cutaneous aging: intrinsic aging versus photoexposure.

@article{Uitto2008TheRO,
  title={The role of elastin and collagen in cutaneous aging: intrinsic aging versus photoexposure.},
  author={Jouni Uitto},
  journal={Journal of drugs in dermatology : JDD},
  year={2008},
  volume={7 2 Suppl},
  pages={s12-6}
}
  • Jouni Uitto
  • Published 2008 in Journal of drugs in dermatology : JDD
Cutaneous aging occurs through 2 biologically distinct processes: intrinsic and extrinsic aging. The first is a naturally occurring process that results from slow tissue degeneration. In human dermis, intrinsic aging is characterized by 3 features: atrophy of the dermis due to loss of collagen, degeneration in the elastic fiber network, and loss of hydration. In contrast to intrinsic aging, extrinsic aging is due to environmental factors. Since ultraviolet (UV) exposure is the principal cause… CONTINUE READING

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