The role of dystroglycan in PDGF-BB-dependent migration of activated hepatic stellate cells/myofibroblasts.

@article{Kastanis2011TheRO,
  title={The role of dystroglycan in PDGF-BB-dependent migration of activated hepatic stellate cells/myofibroblasts.},
  author={George John Kastanis and Zamira Helena Hern{\'a}ndez-Nazara and Natalia Nieto and Ana Rosa Rinc{\'o}n-S{\'a}nchez and Anastas Popratiloff and Jos{\'e} Alfredo Dom{\'i}nguez-Rosales and Carmen G. Lechuga and Marcos Rojkind},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2011},
  volume={301 3},
  pages={G464-74}
}
Hepatic stellate cells are embedded in the loose connective tissue matrix within the space of Disse. This extracellular matrix contains several basement membrane components including laminin, but its composition changes during liver injury because of the production of extracellular matrix components found in scar tissue. These changes in extracellular matrix composition and in cell-extracellular matrix interactions may play a key role in hepatic stellate cell transdifferentiation. In this… CONTINUE READING

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