The role of dynamics in enzyme activity.

  title={The role of dynamics in enzyme activity.},
  author={Roy M. Daniel and Rachel V Dunn and John L. Finney and Jeremy C. Smith},
  journal={Annual review of biophysics and biomolecular structure},
Although protein function is thought to depend on flexibility, precisely how the dynamics of the molecule and its environment contribute to catalytic mechanisms is unclear. We review experimental and computational work relating to enzyme dynamics and function, including the role of solvent. The evidence suggests that fast motions on the 100 ps timescale, and any motions coupled to these, are not required for enzyme function. Proteins where the function is electron transfer, proton tunneling, or… CONTINUE READING

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