• DOI:10.1038/nrg1746
Corpus ID: 7779574

The role of double-strand break repair — insights from human genetics

@article{ODriscoll2006TheRO,
  title={The role of double-strand break repair — insights from human genetics},
  author={M. O’Driscoll and P. Jeggo},
  journal={Nature Reviews Genetics},
  year={2006},
  volume={7},
  pages={45-54}
}

M. O’Driscoll, P. Jeggo

Published 2006

Medicine, Biology

Nature Reviews Genetics

The efficient repair of DNA double-strand breaks is crucial in safeguarding the genomic integrity of organisms. Responses to double-strand breaks include complex signal-transduction, cell-cycle-checkpoint and repair pathways. Defects in these pathways lead to several human disorders with pleiotropic clinical features. Dissection of the molecular basis that underlies the diverse clinical features is enhancing our understanding of the damage-response mechanisms and their role in development, and… CONTINUE READING

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