The role of dopamine in the nucleus accumbens in analgesia.

  title={The role of dopamine in the nucleus accumbens in analgesia.},
  author={Nad{\`e}ge Altier and Jane Stewart},
  journal={Life sciences},
  volume={65 22},
Opioid and psychostimulant drugs have long been used for the relief of chronic pain in the clinical situation. Animal studies confirm that these drugs alleviate persistent or tonic pain. Little is known, however, about the neural systems underlying the suppression of tonic pain except that they are different from those mediating the suppression of phasic (i.e., sharp and short-lasting) pain. Although spinal and brainstem-descending pain suppression mechanisms play a role in mediating the… CONTINUE READING