The role of dopamine in the effects of pentazocine and tripelennamine

  title={The role of dopamine in the effects of pentazocine and tripelennamine},
  author={Thomas J Hudzik and Barbara L. Slifer},
  journal={Pharmacology Biochemistry and Behavior},
  • T. Hudzik, B. Slifer
  • Published 1 July 1990
  • Psychology, Biology
  • Pharmacology Biochemistry and Behavior
Interactions between H1-antagonists and opioids: a drug discrimination study
The results suggest that the potentiation of the cocaine-like discriminative stimulus effects of H1-antagonists by opioids may be involved in the enhanced rewarding effects of combinations of opioids and H1 -antagonists.


The clinical pharmacology of pentazocine and tripelennamine (T's and Blues).
The studies suggest that the antihistamine tripelennamine has abuse potential, and that in combination with pentazocine, the euphoric effects of the opioid are enhanced and its dysphoric properties attenuated.
Intravenous self-administration of dopamine receptor agonists by rhesus monkeys.
The results suggest that a DA receptor that is similar to the DA2 receptor is involved in the reinforcing properties of psychomotor stimulants in rhesus monkeys, and are consistent with the hypothesis that CNS DA is involvement in the reinforcement properties of Psychomotor Stimulants.
Behavioral effects of histamine H1 antagonists: comparison with other drugs and modification by haloperidol.
The behavioral effects of several histamine H1 antagonists were compared in groups of squirrel monkeys trained to respond under fixed-interval schedules involving response-produced shock or
Some behavioral effects of histamine H1 antagonists in squirrel monkeys.
The results show that histamine H1 antagonists can have pronounced rate-increasing effects on nonsuppressed and suppressed behavior, and that they can serve as reinforcers in monkeys.
Effects of psychomotor stimulants, alone and in pairs, on milk drinking in the rat after intraperitoneal and intragastric administration.
Isobolographic analysis of the interactions indicates that d-amphetamine and l-cathinone were infra-additive or additive or additive by both routes of administration, and cocaine and d- methamphetamine tended toward supra-additivity by both Routes.
Naloxone-inaccessible sigma receptor in rat central nervous system.
  • S. Tam
  • Biology, Chemistry
    Proceedings of the National Academy of Sciences of the United States of America
  • 1983
It has been postulated that the psychotomimetic effects of opiates of the benzomorphan series are due to their activity at the sigma receptor, and the drug selectivity and regional distribution of this sigma binding site in the rat central nervous system are different from that of the mu and delta opioid receptors and phencyclidine receptors.
Discriminative stimulus properties of histamine H1-antagonists in animals trained to discriminate d-amphetamine or pentobarbital.
  • S. EvansC. Johanson
  • Biology, Psychology
    The Journal of pharmacology and experimental therapeutics
  • 1989
Pigeons were trained to discriminate i.m. administered d-amphetamine (AMPH) or pentobarbital (PB) from saline with responding maintained under a fixed-ratio 30 schedule of food delivery. Rhesus