The role of dopamine in modulation of Th-17 immune response in multiple sclerosis.

Abstract

Neuromediators may modulate neuroinflammation, particularly in multiple sclerosis (MS). We investigated the effects of dopamine (DA) on the pro-inflammatory Th17-branch of immunity in 43 patients with relapsing-remitting MS and 20 healthy subjects. Serum DA was lower in MS relapse, whereas percentages of blood CD4(+)CD26(+)CD161(+)CD196(+) Th17-cells and production of interleukin-17 (IL-17) and interferon-gamma by anti-CD3/anti-CD28-stimulated peripheral blood mononuclear cells (PBMC) were higher in MS relapse than in remission or healthy subjects. DA suppressed IL-17 production by PBMC from MS patients and healthy subjects. The suppressive effect of DA was abolished in the presence of an antagonist of D2-like receptors (sulpiride). These data suggest an anti-inflammatory role for DA in MS.

DOI: 10.1016/j.jneuroim.2016.01.020

Cite this paper

@article{Melnikov2016TheRO, title={The role of dopamine in modulation of Th-17 immune response in multiple sclerosis.}, author={Mikhail Melnikov and Olga Belousova and Vladimir V Murugin and Мikhail Pashenkov and Alexey Boyко}, journal={Journal of neuroimmunology}, year={2016}, volume={292}, pages={97-101} }