The role of dopamine for the pathophysiology of schizophrenia

  title={The role of dopamine for the pathophysiology of schizophrenia},
  author={Eva M. Meisenzahl and Gisela J. E. Schmitt and Johanna Scheuerecker and Hans-J{\"u}rgen M{\"o}ller},
  journal={International Review of Psychiatry},
  pages={337 - 345}
Since decades, experimental approaches and clinical experience have suggested a dopaminergic system's dysregulation playing an important role within the pathophysiology of schizophrenia. This paper summarizes the actual standard of knowledge of the physiological fundamentals and hypothesized dysbalances of the dopamine (DA) system with respect to schizophrenia including interaction with other neurotransmitter systems (glutamate, GABA). The assumed functional role of DA with respect to… 

The nature of dopamine dysfunction in schizophrenia and what this means for treatment.

The locus of the largest dopaminergic abnormality in schizophrenia is presynaptic, which affects dopamine synthesis capacity, baseline synaptic dopamine levels, and dopamine release, and future drug development should focus on the control of presYNaptic dopamine synthesis and release capacity.

Dopamine transporter density of striatum showed to be increased in Schizophrenia first-episode drug-naïve patients

Elevated density of presynaptic dopamine transporters, may be part of the neuro-pathological abnormality which is associated with dopaminergic activity in schizophrenia.

Structural and functional cerebral changes in patients with schizophrenia and genetic risk-allele carriers

Two aspects of the clinical symptomatology of schizophrenia are analyzed with respect to their potential neurobiological correlate and evidence for the dopamine-hypothesis from in-vivo neuroimaging studies was investigated in a comprehensive meta-analysis.

Striatal presynaptic dopamine in schizophrenia, Part I: meta-analysis of dopamine active transporter (DAT) density.

The data suggest that altered integrity of striatal dopamine synapses is not critical for the emergence of schizophrenia or its treatment, and should be useful in further refining dopaminergic hypotheses of schizophrenia.

From the prodrome to chronic schizophrenia: the neurobiology underlying psychotic symptoms and cognitive impairments.

Evidence links greater dopamine synthesis capacity to poorer cognitive performance and altered frontal cortical function measured using functional imaging during cognitive tasks, and the nature of other neurofunctional alterations in the disorder, in particular in the serotonergic system and neuroinflammation is reviewed.

Presynaptic Dopaminergic Function: Implications for Understanding Treatment Response in Psychosis

All current antipsychotic drugs block dopamine (DA) receptors, but the nature of the DA dysfunction in schizophrenia has not been clear. However, consistent evidence now shows that presynaptic

Abnormal frontostriatal interactions in people with prodromal signs of psychosis: a multimodal imaging study.

In people with prodromal signs of psychosis, there are direct correlations between altered prefrontal cortical function and subcortical dopamine synthesis capacity, consistent with the notion that frontostriatal interactions play a critical role in the pathoetiology of schizophrenia.

Antipsychotic Drugs: Comparison in Animal Models of Efficacy, Neurotransmitter Regulation, and Neuroprotection

The evidence to date suggests that although all antipsychotic drugs have the ability to reduce psychotic symptoms via D2 receptor antagonism, some antipsychotics may differ in other pharmacological properties and their capacities to mitigate and possibly reverse cellular processes that may underlie the pathophysiology of schizophrenia.

Midbrain dopamine function in schizophrenia and depression: a post-mortem and positron emission tomographic imaging study.

Findings indicate that elevated dopamine synthesis capacity is seen in the nigral origin of dopamine neurons as well as their striatal terminals in schizophrenia, and is linked to symptom severity in patients.

Presynaptic dopamine alterations in schizophrenia: Functional or structural defect?




Neurobiology of dopamine in schizophrenia.

Network interactions in schizophrenia — therapeutic implications

Elevated dopa decarboxylase activity in living brain of patients with psychosis.

  • J. ReithC. Benkelfat A. Gjedde
  • Psychology, Medicine
    Proceedings of the National Academy of Sciences of the United States of America
  • 1994
An increase of the rate of metabolism of an exogenous dopa tracer in the neostriatum of a subgroup of patients with a history of psychosis is discovered, consistent with the theory that a state of psychosis arises when episodic dopamine excess is superimposed on a trait of basic dopamine deficiency in the striatum.

Interactions between monoamines, glutamate, and GABA in schizophrenia: new evidence.

A precise identification of neurotransmitter aberrations in schizophrenia will probably provide clues for a better understanding of the disease and for the development of new treatment and prevention strategies.

Increased dopamine transmission in schizophrenia: relationship to illness phases

Up-regulation of the D1 dopamine receptor-interacting protein, calcyon, in patients with schizophrenia.

These findings provide the first evidence that abnormalities in the dopamine system of patients with schizophrenia may lie in altered levels of dopamine receptor-interacting proteins.

Decreased dopamine D2 receptor binding in the anterior cingulate cortex in schizophrenia.

The lower BP values indicate fewer D2 receptors in the anterior cingulate cortex in patients with schizophrenia, suggesting alterations in D2 receptor function in the extrastriatal region may underlie the positive symptoms of schizophrenia.

Presynaptic dopaminergic function in the striatum of schizophrenic patients

Dopamine and the diseased brain.

The hypothesis is examined that phasic dopamine release is associated with salience attribution to external stimuli, insofar as it mediates reward anticipation in the ventral striatum and limbic cortex, habit formation in the dorsal striatum, and working memory function in the prefrontal cortex.

Gating of information flow within the limbic system and the pathophysiology of schizophrenia

  • A. Grace
  • Psychology, Biology
    Brain Research Reviews
  • 2000