Corpus ID: 5867759

The role of dopamine and serotonin in the discriminative stimulus effects of lisuride.

@article{White1982TheRO,
  title={The role of dopamine and serotonin in the discriminative stimulus effects of lisuride.},
  author={F. White and J. Appel},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1982},
  volume={221 2},
  pages={
          421-7
        }
}
  • F. White, J. Appel
  • Published 1982
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • The discriminative stimulus properties of the clinically important ergot derivative lisuride hydrogen maleate (LHM) were investigated by training groups of rats (13 per group) to discriminate either of three training doses of LHM (0.02, 0.08 or 0.32 mg/kg) from saline. Dose-response tests showed that the three LHM cues were specific to the dose used during training and the dose-response curve became more steep as the training dose increased. In substitution tests, the direct dopamine (DA… CONTINUE READING
    28 Citations
    Evidence for a direct dopaminergic effect of lisuride
    • M. Schechter
    • Chemistry, Medicine
    • Pharmacology Biochemistry and Behavior
    • 1984
    • 8
    Dopaminergic and serotonergic mediation of the discriminable effects of ergot alkaloids.
    • 37
    Comparison of the effects of LSD and lisuride on A10 dopamine neurons in the rat
    • 26
    Discriminative profile of MDMA
    • M. Schechter
    • Psychology, Medicine
    • Pharmacology Biochemistry and Behavior
    • 1986
    • 62
    LSD, 5-HT (serotonin), and the evolution of a behavioral assay
    • 25
    Antagonism of a behavioral effect of LSD and lisuride in the cat
    Antagonism of the amphetamine cue by both classical and atypical antipsychotic drugs.
    • 105