The role of dopamine and serotonin in the discriminative stimulus effects of lisuride.

@article{White1982TheRO,
  title={The role of dopamine and serotonin in the discriminative stimulus effects of lisuride.},
  author={Francis J. White and James B. Appel},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1982},
  volume={221 2},
  pages={421-7}
}
The discriminative stimulus properties of the clinically important ergot derivative lisuride hydrogen maleate (LHM) were investigated by training groups of rats (13 per group) to discriminate either of three training doses of LHM (0.02, 0.08 or 0.32 mg/kg) from saline. Dose-response tests showed that the three LHM cues were specific to the dose used during training and the dose-response curve became more steep as the training dose increased. In substitution tests, the direct dopamine (DA… CONTINUE READING