The role of dopamine D3 compared with D2 receptors in the control of locomotor activity: a combined behavioural and neurochemical analysis with novel, selective antagonists in rats

  title={The role of dopamine D3 compared with D2 receptors in the control of locomotor activity: a combined behavioural and neurochemical analysis with novel, selective antagonists in rats},
  author={Mark J Millan and L. Seguin and Alain P. Gobert and Didier Cussac and Mauricette Brocco},
BackgroundThe role of dopamine D3/D2 receptors in the control of locomotion is poorly understood.ObjectivesTo examine the influence of selective antagonists at D3 or D2 receptors on locomotion in rats, alone and in interaction with the preferential D3 versus D2 receptor agonist, PD128,907.MethodsAffinities of ligands at rat D2 and cloned, human hD3, hD2S, hD2L and hD4 sites were determined by standard procedures. Locomotion was monitored automatically in rats pre-habituated for 30 min to an… 
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Differential effects of dopamine D2 and D3 receptor antagonists in regard to dopamine release, in vivo receptor displacement and behaviour
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Central administration of dopamine D3 receptor antisense to rat: effects on locomotion, dopamine release and [3H]spiperone binding
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