The role of disorder in interaction networks: a structural analysis

  title={The role of disorder in interaction networks: a structural analysis},
  author={Philip M. Kim and Andrea Sboner and Yu Xia and Mark B Gerstein},
  journal={Molecular Systems Biology},
  pages={179 - 179}
Recent studies have emphasized the value of including structural information into the topological analysis of protein networks. Here, we utilized structural information to investigate the role of intrinsic disorder in these networks. Hub proteins tend to be more disordered than other proteins (i.e. the proteome average); however, we find this only true for those with one or two binding interfaces ('single'-interface hubs). In contrast, the distribution of disordered residues in multi-interface… CONTINUE READING

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