The role of dietary creatine

@article{Brosnan2016TheRO,
  title={The role of dietary creatine},
  author={Margaret E Brosnan and John T Brosnan},
  journal={Amino Acids},
  year={2016},
  volume={48},
  pages={1785-1791}
}
The daily requirement of a 70-kg male for creatine is about 2 g; up to half of this may be obtained from a typical omnivorous diet, with the remainder being synthesized in the body Creatine is a carninutrient, which means that it is only available to adults via animal foodstuffs, principally skeletal muscle, or via supplements. Infants receive creatine in mother’s milk or in milk-based formulas. Vegans and infants fed on soy-based formulas receive no dietary creatine. Plasma and muscle creatine… Expand
Creatine synthesis and methionine partitioning during TPN in Yucatan miniature piglets
Methionine is an indispensable amino acid in the diet of neonates and has a metabolic role in the synthesis of creatine, phosphatidylcholine (PC) as well as protein synthesis and otherExpand
A Review Of Creatine And Its Role In Muscle Strength And Balance
TLDR
An overview of recent literature on creatine is provided to expand current understanding of the many roles of this important nutritional compound related to health, disease, and physical activity. Expand
Methionine Nutrition and Metabolism: Insights from Animal Studies to Inform Human Nutrition.
  • R. Elango
  • Chemistry, Medicine
  • The Journal of nutrition
  • 2020
TLDR
Some broad aspects of human methionine nutrition are touched, including requirements in different life stages, disease, and bioavailability, with some examples from the insights/lessons learned from experiments initially conducted in animals. Expand
TMAO, creatine and 1-methylhistidine in serum and urine are potential biomarkers of cod and salmon intake: a randomised clinical trial in adults with overweight or obesity
TLDR
Cod and salmon intake did not affect serum and urine concentrations of 3-methylhistidine, and only marginally affected concentrations of free amino acids and amino acid metabolites, and 1-MeHis measured in serum or urine is a potential biomarker of salmon intake. Expand
Role of Creatine in the Heart: Health and Disease
TLDR
Pending additional trials, creatine supplementation in heart failure may be useful given data showing its effectiveness against specific parameters of heart failure, and against the decrease in muscle strength and endurance of heart Failure patients. Expand
Evolutionary expression differences of creatine synthesis-related genes: Implications for skeletal muscle metabolism in fish
TLDR
Differences in amino acid metabolism along with methionine adenosyltransferase gene expression in muscle from fishes but not mammals further support a central metabolic role of muscle in fish, and hence different organization of the creatine/phosphocreatine biosynthesis system in higher and lower vertebrates. Expand
Common questions and misconceptions about creatine supplementation: what does the scientific evidence really show?
TLDR
An internationally renowned team of research experts was formed to perform an evidence-based scientific evaluation of the literature regarding creatine supplementation, which shows that creatine supplementation is relatively well tolerated, especially at recommended dosages. Expand
Amino Acid Metabolism in the Kidneys: Nutritional and Physiological Significance.
TLDR
Understanding the functions and metabolism of AAs in kidneys is essential for maintaining whole-body homeostasis, improving health and well-being, and preventing or treating renal metabolic diseases in humans and farm animals. Expand
Effect of Creatine Supplementation on the Airways of Youth Elite Soccer Players
TLDR
On the basis of the observed trends and medium to large effect sizes, it cannot exclude that creatine supplementation has an adverse effect on the airways of elite athletes, particularly in those with allergic sensitization. Expand
Human urine 1H NMR metabolomics reveals alterations of the protein and carbohydrate metabolism when comparing habitual Average Danish diet vs. healthy New Nordic diet.
TLDR
Findings from this study provided new insights into the effects of a healthy diet on glycemia, reduction of inflammation, and weight loss among obese individuals, and alteration of the gut microbiota metabolism. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 55 REFERENCES
Creatine and guanidinoacetate content of human milk and infant formulas: implications for creatine deficiency syndromes and amino acid metabolism
TLDR
This is the first time that it has been shown that neonatal creatine accretion is largely due to de novo synthesis and not through dietary intake of creatine, which has important implications both for infants suffering from creatine deficiency syndromes and for neonatal amino acid metabolism. Expand
Creatine: endogenous metabolite, dietary, and therapeutic supplement.
TLDR
It is evident that creatine plays a critical, though underappreciated, role in brain function. Expand
Creatine metabolism and the urea cycle.
TLDR
It is clear that patients with urea cycle disorders also have altered creatine metabolism, and there is some evidence that this may decrease brain creatine levels which may contribute to the neurological symptoms exhibited by these patients. Expand
Changes of tissue creatine concentrations upon oral supplementation of creatine-monohydrate in various animal species.
TLDR
Investigation of changes of total creatine concentrations in brain, muscle, heart, kidney, liver, lung and venous/portal plasma of guinea pigs, mice and rats in response to 2-8 weeks oral creatine-monohydrate supplementation suggests a major determinant of creatine uptake is an extra-intracellular concentration gradient. Expand
Plasma guanidino compounds are altered by oral creatine supplementation in healthy humans.
TLDR
The decrease in circulating guanidinoacetate levels suggests that exogenous supply of creatine chronically inhibits endogenous synthesis at the transamidinase step in humans, supporting earlier animal studies showing a powerful repressive effect of creatine on l-arginine:glycine amidinotransferase. Expand
Absorption of creatine supplied as a drink, in meat or in solid form
TLDR
It is concluded that creatine administered as meat or in solid form is readily absorbed but may result in slightly lower peak concentrations than when the same dose is ingested as a solution. Expand
Oral supplementations of betaine, choline, creatine and vitamin B6 and their influence on the development of homocysteinaemia in neonatal piglets
TLDR
It appears possible to reduce pHcy concentrations in suckling piglets but a combination of all chosen nutrients is required. Expand
Creatine supplementation prevents the accumulation of fat in the livers of rats fed a high-fat diet.
TLDR
In conclusion, creatine supplementation prevented the fatty liver induced by feeding rats a HF diet, probably by normalization of the expression of key genes of β-oxidation. Expand
Low-Dose Creatine Supplementation Lowers Plasma Guanidinoacetate, but Not Plasma Homocysteine, in a Double-Blind, Randomized, Placebo-Controlled Trial.
TLDR
The findings indicate that whereas creatine supplementation downregulates endogenous creatine synthesis, this may not on average lower plasma tHcys in humans, but did decrease in those participants who experienced a decline in plasma guanidinoacetate while receiving creatine plus folic acid supplementation. Expand
Synthesis of guanidinoacetate and creatine from amino acids by rat pancreas
TLDR
It is found that pancreatic acini had measurable activities of both AGAT and GAMT and the capacity to synthesise GAA and creatine from amino acids and that dietary creatine increased the concentrations of GAA, creatine and phosphocreatine in the pancreas. Expand
...
1
2
3
4
5
...