The role of dendritic cells in regulating mucosal immunity and tolerance.

  title={The role of dendritic cells in regulating mucosal immunity and tolerance.},
  author={Allan McI Mowat and Anne M. Donachie and Lucy Ann Parker and Neil C. Robson and Helen Beacock-Sharp and Lindsay J McIntyre and Owain Richard Millington and Fernando Gabriel Chirdo},
  journal={Novartis Foundation symposium},
  pages={291-302; discussion 302-5}
The intestinal immune system discriminates between invasive pathogens and antigens that are harmless, such as food proteins and commensal bacteria. The latter groups of antigens normally induce tolerance and a breakdown in this homeostatic process can lead to diseases such as coeliac disease or Crohn's disease. The nature ofthe intestinal immune response depends on how antigen is presented to CD4+ T cells by dendritic cells (DCs). Both oral tolerance and priming are influenced by the numbers… CONTINUE READING


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