The role of dendritic cell C‐type lectin receptors in HIV pathogenesis

  title={The role of dendritic cell C‐type lectin receptors in HIV pathogenesis},
  author={Stuart G. Turville and John IV Wilkinson and Paul U. Cameron and Joanne Dable and Anthony L. Cunningham},
  journal={Journal of Leukocyte Biology},
Dendritic cells play a major role in HIV pathogenesis. Epithelial dendritic cells appear to be one of the first cells infected after sexual transmission and transfer of the virus to CD4 lymphocytes, simultaneously activating these cells to produce high levels of HIV replication. Such transfer may occur locally in inflamed mucosa or after dendritic cells have matured and migrated to local lymph nodes. Therefore, the mechanism of binding, internalization, infection and transfer of HIV to CD4… 

The role of human dendritic cells in HIV-1 infection.

Advances in the role of DCs during HIV-1 infection are summarized and their potential involvement in the development of preventive strategies against HIV- 1 and other sexually transmitted infections are discussed.

Efficient transfer of HIV-1 in trans and in cis from Langerhans dendritic cells and macrophages to autologous T lymphocytes

The role of macrophages is emphasized in the rapid transmission of HIV to T lymphocytes at mucosal sites, dendritic cells being prone to migration to lymphoid organ for subsequent dissemination by cis transfer.

Antiviral immune responses by human langerhans cells and dendritic cells in HIV-1 infection.

This chapter gives an update on immune responses elicited against viruses and sheds a light on different immune mechanisms that are hijacked by HIV-1 to infect the host.

HIV Induces Maturation of Monocyte-Derived Dendritic Cells and Langerhans Cells1

HIV initiates maturation of DCs which could facilitate subsequent enhanced transfer to T cells, suggesting both viral replication-dependent and -independent mechanisms.

HIV-1 and the hijacking of dendritic cells: a tug of war

  • M. Larsson
  • Biology
    Springer Seminars in Immunopathology
  • 2004
The most dramatic effect seen on the immune system during untreated HIV-1 infection is the destruction of helper CD4+ T cells, which leads to subsequent immune deficiency, however, the immunomodulatory effects of HIV- 1 on different dendritic cell subpopulations may also play an important role in the pathogenesis of AIDS.

The C-type lectin surface receptor DCIR acts as a new attachment factor for HIV-1 in dendritic cells and contributes to trans- and cis-infection pathways.

It is demonstrated that a cell surface molecule designated DCIR (for DC immunoreceptor), a member of a recently described family of DC-expressing CLRs, can participate in the capture of HIV-1 and promote infection in trans and in cis of autologous CD4(+) T cells from human immature monocyte-derived DCs.

Macrophages Transmit Human Immunodeficiency Virus Type 1 Products to CD4-Negative Cells: Involvement of Matrix Metalloproteinase 9

It was found that an HIV-1-dependent increase in matrix metalloproteinase 9 production from donor cells significantly contributed to the cell-to-cell transmission of the viral products and may have a significant role in AIDS pathogenesis.

Macrophages and HIV-1: dangerous liaisons.

The role of Langerhans cells in the sexual transmission of HIV.

HIV and cells of macrophage/dendritic lineage and other non‐T cell reservoirs: new answers yield new questions

This issue of JLB contains several reviews and original reports resulting from the Fifth International Workshop on HIV and Cells of Macrophage/Dendritic Lineage and Other Reservoirs that address recent progress and highlight the current research questions regarding these cell types.



Diversity of receptors binding HIV on dendritic cell subsets

Primary DCs for the receptors involved in viral envelope attachment are characterized and it is observed that C-type lectin receptor (CLR) binding was predominant in skin DCs, whereas binding to emigrating and tonsil DCs was CD4-dependent.

Involvement of macrophage mannose receptor in the binding and transmission of HIV by macrophages

A substantial role for MMR is suggested in the binding and transmission of HIV‐1 by macrophages and this decrease in viral longevity is due to rapid internalization of macrophage‐bound HIV.

Dendritic cells and the replication of HIV‐1

The literature leads to the hypothesis that HIV‐1 infection is a battleground in which DCs could be leading both of the armies, the aggressor that promotes HIV‐ 1 replication from relatively small numbers of infected cells and the defender that mediates T cell‐dependent resistance.

Dendritic cells express multiple chemokine receptors used as coreceptors for HIV entry.

The presence of multiple chemokine receptors on dendritic cells (DC) that may function as coreceptors for HIV entry is identified and identified, providing evidence for the presence of a non-CXCR4 SDF-1 receptor on DC that is used mainly by T-tropic strains of HIV.

HIV gp120 receptors on human dendritic cells.

A novel biotinylated gp120 assay was used to determine whether CLR or CD4 were predominant receptors on monocyte-derived DCs and ex vivo blood DCs, and confirmed that CLRs were the major receptors for gp120 on MDDCs.

Productive infection of dendritic cells by HIV-1 and their ability to capture virus are mediated through separate pathways.

It is suggested that strategies designed to block mucosal transmission of HIV should consider interfering with both virus infection and virus capture by DC.

Bitter-sweet symphony: defining the role of dendritic cell gp120 receptors in HIV infection.

  • S. TurvilleP. Cameron A. Cunningham
  • Biology, Medicine
    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
  • 2001

Recruitment of HIV and Its Receptors to Dendritic Cell-T Cell Junctions

It is proposed that contact between dendritic cells and T cells facilitates transmission of HIV by locally concentrating virus, receptor, and coreceptor during the formation of an infectious synapse.