The role of dendritic cell C‐type lectin receptors in HIV pathogenesis

@article{Turville2003TheRO,
  title={The role of dendritic cell C‐type lectin receptors in HIV pathogenesis},
  author={Stuart G. Turville and John IV Wilkinson and Paul U. Cameron and Joanne Dable and Anthony L Cunningham},
  journal={Journal of Leukocyte Biology},
  year={2003},
  volume={74}
}
Dendritic cells play a major role in HIV pathogenesis. Epithelial dendritic cells appear to be one of the first cells infected after sexual transmission and transfer of the virus to CD4 lymphocytes, simultaneously activating these cells to produce high levels of HIV replication. Such transfer may occur locally in inflamed mucosa or after dendritic cells have matured and migrated to local lymph nodes. Therefore, the mechanism of binding, internalization, infection and transfer of HIV to CD4… 

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Macrophages and HIV-1: dangerous liaisons.

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  • S. TurvilleP. Cameron A. Cunningham
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    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
  • 2001

Recruitment of HIV and Its Receptors to Dendritic Cell-T Cell Junctions

It is proposed that contact between dendritic cells and T cells facilitates transmission of HIV by locally concentrating virus, receptor, and coreceptor during the formation of an infectious synapse.
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